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Issue 20, 2005
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Artificial metallonucleases

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Abstract

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.

Graphical abstract: Artificial metallonucleases

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Publication details

The article was received on 02 Dec 2004, accepted on 25 Jan 2005 and first published on 22 Feb 2005


Article type: Feature Article
DOI: 10.1039/B418164F
Citation: Chem. Commun., 2005,0, 2540-2548
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    Artificial metallonucleases

    F. Mancin, P. Scrimin, P. Tecilla and U. Tonellato, Chem. Commun., 2005, 0, 2540
    DOI: 10.1039/B418164F

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