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Issue 9, 2005
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Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

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Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Graphical abstract: Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

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Publication details

The article was received on 23 Sep 2004, accepted on 24 Nov 2004 and first published on 17 Jan 2005


Article type: Communication
DOI: 10.1039/B414781B
Citation: Chem. Commun., 2005, 1179-1181
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    Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

    S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, W. Laosripaiboon, T. J. Simpson and C. M. Thomas, Chem. Commun., 2005, 1179
    DOI: 10.1039/B414781B

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