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Issue 1, 2005
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A method for rapid reaction optimisation in continuous-flow microfluidic reactors using online Raman spectroscopic detection

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Abstract

An extremely rapid tool for continuous flow synthetic process optimisation is described. A microfluidic reaction system operating in continuous flow is used in conjunction with confocal Raman microscopy to afford rapid molecule synthesis and product quantitation. Accordingly, the approach allows for rapid reaction optimisation within a continuous flow system. Specifically, the catalytic oxidation of isopropyl alcohol (IPA) to acetone using tetra-N-propylammonium perruthanate (TPAP)/N-methylmorpholine N-oxide (NMO) in a radial interdigitated micromixer is studied as a model reaction system. The composition of the reaction effluent can be determined with great facility and information relating to catalyst/co-oxidant ratios, catalyst turnovers and reaction endpoints extracted. Specifically, variation of catalyst and co-oxidant volumetric flow rates between 0 and 50 µL min−1 is used to vary reactant concentrations, define reaction residence times and control product conversions between 0 and 100%. The rapid nature of the system allows chemical information to be gathered and utilised on a sub-minute timescale.

Graphical abstract: A method for rapid reaction optimisation in continuous-flow microfluidic reactors using online Raman spectroscopic detection

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Publication details

The article was received on 05 Aug 2004, accepted on 26 Oct 2004 and first published on 22 Nov 2004


Article type: Paper
DOI: 10.1039/B412069H
Citation: Analyst, 2005,130, 46-51
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    A method for rapid reaction optimisation in continuous-flow microfluidic reactors using online Raman spectroscopic detection

    S. Leung, R. F. Winkle, R. C. R. Wootton and A. J. deMello, Analyst, 2005, 130, 46
    DOI: 10.1039/B412069H

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