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Issue 8, 2004
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The photoreactivity of ocular lipofuscin

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Abstract

Lipofuscin or “age pigment” is a lipid–protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss.

Graphical abstract: The photoreactivity of ocular lipofuscin

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Publication details

The article was received on 06 Jan 2004, accepted on 21 Jun 2004 and first published on 06 Jul 2004


Article type: Perspective
DOI: 10.1039/B400108G
Citation: Photochem. Photobiol. Sci., 2004,3, 759-764
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    The photoreactivity of ocular lipofuscin

    M. Boulton, M. Rózanowska, B. Rózanowski and T. Wess, Photochem. Photobiol. Sci., 2004, 3, 759
    DOI: 10.1039/B400108G

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