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Issue 19, 2004
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Deoxyribozymes: DNA catalysts for bioorganic chemistry

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Abstract

Deoxyribozymes are DNA molecules with catalytic activity. For historical and practical reasons, essentially all reported deoxyribozymes catalyze reactions of nucleic acid substrates, although this is probably not a fundamental limitation. In vitro selection strategies have been used to identify many deoxyribozymes that catalyze RNA cleavage, RNA and DNA ligation, and a variety of covalent modification reactions of nucleic acid substrates. Many deoxyribozymes are capable of catalysis with substantial rate enhancements reaching up to 1010-fold over background, and their very high selectivities would often be difficult or impossible to achieve using traditional organic synthesis approaches. This report summarizes the current utility and potential future applications of deoxyribozymes from the bioorganic chemistry perspective.

Graphical abstract: Deoxyribozymes: DNA catalysts for bioorganic chemistry

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Publication details

The article was received on 03 Aug 2004, accepted on 11 Aug 2004 and first published on 03 Sep 2004


Article type: Emerging Area
DOI: 10.1039/B411910J
Citation: Org. Biomol. Chem., 2004,2, 2701-2706
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    Deoxyribozymes: DNA catalysts for bioorganic chemistry

    S. K. Silverman, Org. Biomol. Chem., 2004, 2, 2701
    DOI: 10.1039/B411910J

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