Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 19, 2004
Previous Article Next Article

Deoxyribozymes: DNA catalysts for bioorganic chemistry

Author affiliations


Deoxyribozymes are DNA molecules with catalytic activity. For historical and practical reasons, essentially all reported deoxyribozymes catalyze reactions of nucleic acid substrates, although this is probably not a fundamental limitation. In vitro selection strategies have been used to identify many deoxyribozymes that catalyze RNA cleavage, RNA and DNA ligation, and a variety of covalent modification reactions of nucleic acid substrates. Many deoxyribozymes are capable of catalysis with substantial rate enhancements reaching up to 1010-fold over background, and their very high selectivities would often be difficult or impossible to achieve using traditional organic synthesis approaches. This report summarizes the current utility and potential future applications of deoxyribozymes from the bioorganic chemistry perspective.

Graphical abstract: Deoxyribozymes: DNA catalysts for bioorganic chemistry

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 03 Aug 2004, accepted on 11 Aug 2004 and first published on 03 Sep 2004

Article type: Emerging Area
DOI: 10.1039/B411910J
Citation: Org. Biomol. Chem., 2004,2, 2701-2706
  •   Request permissions

    Deoxyribozymes: DNA catalysts for bioorganic chemistry

    S. K. Silverman, Org. Biomol. Chem., 2004, 2, 2701
    DOI: 10.1039/B411910J

Search articles by author