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Issue 7, 2004
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A novel phase-switching protecting group for multi-step parallel solution phase synthesis

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Abstract

A new phase-tag 1 which facilitates the parallel solution phase synthesis of carboxylic acids, esters, and carboxamides is reported. The new phase tag assists compound purification by enabling the selective resin capture of reaction products in either a reversible pH dependent manner (solid-phase extraction), or irreversibly in a Diels–Alder reaction.

Graphical abstract: A novel phase-switching protecting group for multi-step parallel solution phase synthesis

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Publication details

The article was received on 07 Jan 2004, accepted on 28 Jan 2004 and first published on 25 Feb 2004


Article type: Paper
DOI: 10.1039/B400110A
Citation: Org. Biomol. Chem., 2004,2, 989-998
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    A novel phase-switching protecting group for multi-step parallel solution phase synthesis

    X. Li, C. Abell, M. S. Congreve, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2004, 2, 989
    DOI: 10.1039/B400110A

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