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Issue 19, 2004
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Bromine catalyzed conversion of S-tert-butyl groups into versatile and, for self-assembly processes accessible, acetyl-protected thiols

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Abstract

The facile and efficient conversion of a tert-butyl protecting group to an acetyl protecting group for thiols by catalytic amounts of bromine in acetyl chloride and the presence of acetic acid has been developed. The fairly mild reaction conditions are of particular interest for new protecting group strategies for sulfur functionalised target structures.

Graphical abstract: Bromine catalyzed conversion of S-tert-butyl groups into versatile and, for self-assembly processes accessible, acetyl-protected thiols

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Publication details

The article was received on 08 Jun 2004, accepted on 01 Sep 2004 and first published on 13 Sep 2004


Article type: Communication
DOI: 10.1039/B408677E
Citation: Org. Biomol. Chem., 2004,2, 2722-2724
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    Bromine catalyzed conversion of S-tert-butyl groups into versatile and, for self-assembly processes accessible, acetyl-protected thiols

    A. Błaszczyk, M. Elbing and M. Mayor, Org. Biomol. Chem., 2004, 2, 2722
    DOI: 10.1039/B408677E

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