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Issue 16, 2004
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Nucleophilic trifluoromethylation of cyclic imides using (trifluoromethyl)trimethylsilane CF3SiMe3

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Abstract

A variety of cyclic five-membered imides was trifluoromethylated in good to excellent chemical yields using (trifluoromethyl)trimethylsilane CF3SiMe3 under fluoride ion catalysis. The method was successfully applied to the stereoselective synthesis of trifluoromethylated bi- and tricyclic lactams which could serve as precursors for designed thrombin inhibitors.

Graphical abstract: Nucleophilic trifluoromethylation of cyclic imides using (trifluoromethyl)trimethylsilane CF3SiMe3

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Publication details

The article was received on 19 May 2004, accepted on 08 Jul 2004 and first published on 27 Jul 2004


Article type: Communication
DOI: 10.1039/B407555B
Citation: Org. Biomol. Chem., 2004,2, 2267-2269
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    Nucleophilic trifluoromethylation of cyclic imides using (trifluoromethyl)trimethylsilane CF3SiMe3

    A. Hoffmann-Röder, P. Seiler and F. Diederich, Org. Biomol. Chem., 2004, 2, 2267
    DOI: 10.1039/B407555B

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