Jump to main content
Jump to site search

Issue 8, 2004
Previous Article Next Article

Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome

Author affiliations

Abstract

Guillain-Barré syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these ganglioside structures are highly enriched. Truncated gangliosides representive of GD3, GQ1b and GM2 epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether. The synthetic oligosaccharide ligands are structural mimics of these highly complex ganglioside epitopes and via their ability to neutralize or remove auto-antibodies have the potential for therapy, either as soluble blocking ligands administered systemically, or as immuno-affinity ligands for use as extracorporeal immunoadsorbents.

Graphical abstract: Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome

Back to tab navigation

Publication details

The article was received on 06 Jan 2004, accepted on 16 Feb 2004 and first published on 15 Mar 2004


Article type: Paper
DOI: 10.1039/B400029C
Citation: Org. Biomol. Chem., 2004,2, 1199-1212
  •   Request permissions

    Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome

    S. M. Andersen, C. Ling, P. Zhang, K. Townson, H. J. Willison and D. R. Bundle, Org. Biomol. Chem., 2004, 2, 1199
    DOI: 10.1039/B400029C

Search articles by author

Spotlight

Advertisements