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Issue 3, 2004
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Synthesis and bio-assay of RCM-derived Bowman–Birk inhibitor analogues

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Abstract

Bowman–Birk inhibitor analogues containing 2, 3 and 4-carbon analogues of the natural disulfide were synthesised via solid phase microwave-assisted RCM and found to have Ki values against chymotrypsin in the low to sub-micromolar range, the best replacement for the disulfide arising from the linkage by RCM of two L-homoallylglycine residues.

Graphical abstract: Synthesis and bio-assay of RCM-derived Bowman–Birk inhibitor analogues

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Publication details

The article was received on 15 Oct 2003, accepted on 16 Dec 2003 and first published on 24 Dec 2003


Article type: Communication
DOI: 10.1039/B312908J
Citation: Org. Biomol. Chem., 2004,2, 281-283
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    Synthesis and bio-assay of RCM-derived Bowman–Birk inhibitor analogues

    S. M. Miles, R. J. Leatherbarrow, S. P. Marsden and W. J. Coates, Org. Biomol. Chem., 2004, 2, 281
    DOI: 10.1039/B312908J

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