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Issue 14, 2004
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Magnetic nanoparticle design for medical diagnosis and therapy

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Abstract

Magnetic nanoparticles have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint (e.g. relaxivity for MRI and specific absorption rate for hyperthermia), the factors affecting their biodistribution (e.g. size, surface hydrophobic/hydrophilic balance, etc.) and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells.

Graphical abstract: Magnetic nanoparticle design for medical diagnosis and therapy

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Publication details

The article was received on 10 Feb 2004, accepted on 19 Apr 2004 and first published on 02 Jun 2004


Article type: Feature Article
DOI: 10.1039/B402025A
Citation: J. Mater. Chem., 2004,14, 2161-2175
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    Magnetic nanoparticle design for medical diagnosis and therapy

    S. Mornet, S. Vasseur, F. Grasset and E. Duguet, J. Mater. Chem., 2004, 14, 2161
    DOI: 10.1039/B402025A

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