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Issue 14, 2004
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Control of octacalcium phosphate and apatite crystal growth by amelogenin matrices

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Abstract

Tooth enamel, the hardest bioceramic composite in the vertebrate body, is the result of a cascade of intra- and extracellular events. Amelogenins, the principal extracellular matrix protein component of mineralizing enamel, have been considered to play substantial roles in controlling the growth and organization of enamel crystals. Considering octacalcium phosphate (OCP) as a precursor phase of enamel apatite crystallites, we have developed in vitro systems to grow OCP and apatite crystals in amelogenin matrices and therefore to investigate amelogenin–OCP and amelogenin–apatite interactions. This paper reviews our current findings on the effect of amelogenin on the morphology, size, phase and orientation of such crystals.

Graphical abstract: Control of octacalcium phosphate and apatite crystal growth by amelogenin matrices

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Publication details

The article was received on 09 Feb 2004, accepted on 26 Apr 2004 and first published on 16 Jun 2004


Article type: Feature Article
DOI: 10.1039/B401961J
Citation: J. Mater. Chem., 2004,14, 2189-2199
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    Control of octacalcium phosphate and apatite crystal growth by amelogenin matrices

    M. Iijima and J. Moradian-Oldak, J. Mater. Chem., 2004, 14, 2189
    DOI: 10.1039/B401961J

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