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Issue 18, 2004
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Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications

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Abstract

A new approach to prepare surface-functionalized magnetic nanoparticles by synthesis of poly(methacrylic acid) (PMAA) coated maghemite nanoparticles in aqueous solution is reported. Maghemite (γ-Fe2O3) nanoparticles with an average diameter of 8 ± 2 nm were fabricated and subsequently coated with PMAA by emulsion polymerization. The FTIR study and thermal analysis confirmed the chemical adsorption of methacrylic acid on the maghemite nanoparticle surface, and suggested a symmetrical carboxylate bonding. The free carboxyl group of PMAA, which was verified by FTIR spectroscopy and zeta potential measurement, provided the site for immobilization of foreign molecules. The PMAA coated maghemite nanoparticles were demonstrated as potential magnetically targeted drug carriers by adsorbing an anti-cancer drug (carboplatin) via the ion–dipole interaction between CO2 of PMAA and carboplatin.

Graphical abstract: Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications

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Publication details

The article was received on 02 Apr 2004, accepted on 04 Jun 2004 and first published on 28 Jul 2004


Article type: Paper
DOI: 10.1039/B404964K
Citation: J. Mater. Chem., 2004,14, 2781-2786
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    Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications

    S. Yu and G. M. Chow, J. Mater. Chem., 2004, 14, 2781
    DOI: 10.1039/B404964K

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