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Lipase catalysed resolution of the Lotrafiban intermediate 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester in ionic liquids: comparison to the industrial t-butanol process

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The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, UK
Technical Development Department, GlaxoSmithKline, North Lonsdale Road, Ulverston, UK
Synthetic Chemistry, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, UK
GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
Green Chem., 2004,6, 475-482

DOI: 10.1039/B405712K
Received 16 Apr 2004, Accepted 01 Jul 2004
First published online 06 Sep 2004
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