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Paper

Lipase catalysed resolution of the Lotrafiban intermediate 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester in ionic liquids: comparison to the industrial t-butanol process

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Corresponding authors
a
The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, UK
b
Technical Development Department, GlaxoSmithKline, North Lonsdale Road, Ulverston, UK
c
Synthetic Chemistry, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, UK
d
GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
Green Chem., 2004,6, 475-482

DOI: 10.1039/B405712K
Received 16 Apr 2004, Accepted 01 Jul 2004
First published online 06 Sep 2004
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