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Issue 4, 2004
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Palladium-free and ligand-free Sonogashira cross-coupling

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Abstract

Copper nanoclusters catalyse the cross-coupling of alkynes and aryl halides to give the corresponding disubstituted alkynes. No palladium, ligand, or co-catalyst is needed, and products are isolated in good yields (80–85%) and high selectivity. The clusters are simple to prepare, stable and can be applied to a variety of iodo- and bromoaryls. Mechanistic pathways for homocoupling and cross-coupling of alkynes are examined by comparing the activity of different catalyst and co-catalyst combinations. The copper clusters show different catalytic properties than their homogeneous analogues.

Graphical abstract: Palladium-free and ligand-free Sonogashira cross-coupling

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Publication details

The article was received on 03 Feb 2004, accepted on 03 Mar 2004 and first published on 19 Mar 2004


Article type: Paper
DOI: 10.1039/B401586J
Citation: Green Chem., 2004,6, 215-218
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    Palladium-free and ligand-free Sonogashira cross-coupling

    M. B. Thathagar, J. Beckers and G. Rothenberg, Green Chem., 2004, 6, 215
    DOI: 10.1039/B401586J

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