Issue 11, 2004
From the journal:

Journal of Environmental Monitoring

Simultaneous determination of 2-phenylbenzotriazole-type mutagens, PBTA-1 through -8, in river water by liquid chromatography–tandem mass spectrometry

Hiroshi Moriwaki,*a   Hiroya Harino,a   Taro Yoshikura,a   Takeshi Ohe,b   Haruo Nukaya,c   Yoshiyasu Terao,d   Hiroyuki Sawanishi,e   Keiji Wakabayashi,f   Hidekazu Miyakodag  and  Jean-François Alaryh  

* Corresponding authors

a Osaka City Institute of Public Health & Environmental Sciences, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan
E-mail: hiroshi.moriwaki@iphes.city.osaka.jp

b Department of Food and Nutrition, Kyoto Women’s University, Kitahiyoshi-cho, Imakumano, Higashiyama-ku, Kyoto 605-8501, Japan

c School of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, Japan

d Graduate School of Nutrition and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

e Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa 920-1181, Japan

f Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan

g Applied Biosystems Japan Ltd., 4-5-4, Hatchobori, Chuo-ku, Tokyo 104-0032, Japan

h Applied Biosystems/MDS Sciex, Toronto, 71 Four Valley Drive, Concord, Ontario, Canada

Abstract

We describe a method for the simultaneous determination of eight kinds of phenylbenzotriazole-type mutagens (PBTA-1, -2, -3, -4, -5, -6, -7 and -8) in river water based on liquid chromatography–tandem mass spectrometry (LC/MS/MS). The application of dopant-assisted atmospheric pressure photoionization (APPI) for the detection of the PBTAs was studied. The APPI technique provided higher PBTA signal intensities than those obtained with an electrospray ionization (ESI) source, and the APPI method was used for the determination of the PBTAs. A solid-phase extraction procedure was used for the extractions of PBTA-1 through -8 from river water. The procedure was rapid and the relative standard deviations were below 15%. The detection limits of PBTA-1 through -8 in river water using the proposed method were found to range from 0.04 to 0.5 ng L−1 and PBTAs were successfully detected in river water at sub-ng L−1 levels.

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Article information

DOI
https://doi.org/10.1039/B403965N
Article type
Paper
Submitted
15 Mar 2004
Accepted
03 Aug 2004
First published
14 Oct 2004

J. Environ. Monit., 2004,6, 897-902

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Simultaneous determination of 2-phenylbenzotriazole-type mutagens, PBTA-1 through -8, in river water by liquid chromatography–tandem mass spectrometry

H. Moriwaki, H. Harino, T. Yoshikura, T. Ohe, H. Nukaya, Y. Terao, H. Sawanishi, K. Wakabayashi, H. Miyakoda and J. Alary, J. Environ. Monit., 2004, 6, 897 DOI: 10.1039/B403965N

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