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Issue 5, 2004
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Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex

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Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1 and a rate enhancement of 1.55 × 108.

Graphical abstract: Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

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Publication details

The article was received on 29 Jan 2004, accepted on 02 Feb 2004 and first published on 05 Feb 2004


Article type: Communication
DOI: 10.1039/B401383B
Citation: Dalton Trans., 2004, 697-698
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    Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex

    S. Dhar, P. A. N. Reddy and A. R. Chakravarty, Dalton Trans., 2004, 697
    DOI: 10.1039/B401383B

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