Jump to main content
Jump to site search

Issue 1, 2004
Previous Article Next Article

The Pauson–Khand reaction, a powerful synthetic tool for the synthesis of complex molecules

Author affiliations

Abstract

There are still some synthetic chemists who hesitate to use metal-mediated or -catalysed reactions. The Pauson–Khand reaction (PKR) is a powerful transformation that has now been sufficiently well developed to be routinely considered when planning a synthesis, especially of polycyclic complex molecules. This tutorial review aims to encourage the use of this process explaining the best ways of performing a PKR both in the stoichiometric and the catalytic version, showing the scope of the process and its limitations. Additionally, asymmetry can be introduced in the reaction using several strategies, which will be discussed. The most recent examples of the synthetic applications of the PKR in natural product synthesis will give the reader an idea of the great usefulness of this reaction.

Graphical abstract: The Pauson–Khand reaction, a powerful synthetic tool for the synthesis of complex molecules

Back to tab navigation

Publication details

The article was received on 11 Jun 2003 and first published on 27 Nov 2003


Article type: Tutorial Review
DOI: 10.1039/B300976A
Citation: Chem. Soc. Rev., 2004,33, 32-42
  •   Request permissions

    The Pauson–Khand reaction, a powerful synthetic tool for the synthesis of complex molecules

    J. Blanco-Urgoiti, L. Añorbe, L. Pérez-Serrano, G. Domínguez and J. Pérez-Castells, Chem. Soc. Rev., 2004, 33, 32
    DOI: 10.1039/B300976A

Search articles by author

Spotlight

Advertisements