Issue 17, 2004
From the journal:

Chemical Communications

Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy†

Hiroyuki Nakamura,*a   Yusuke Miyajima,a   Toshiaki Takei,b   Satoshi Kasaokac  and  Kazuo Maruyamac  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan
E-mail: hiroyuki.nakamura@gakushuin.ac.jp
Fax: 81 3 5992 1029
Tel: 81 3 3986 0221

b Institute for Molecular Biology, Gakushuin University, Tokyo 171-8588, Japan

c Department of Biopharmaceutics, School of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-0195, Japan

Abstract

The nido-carborane lipid 2, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid 2 formed a stable vesicle in which calcein was encapsulated. The lipid 2 was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration.

Graphical abstract: Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B406141A
Article type
Communication
Submitted
23 Apr 2004
Accepted
21 Jun 2004
First published
29 Jul 2004

Chem. Commun., 2004, 1910-1911

Permissions

Request permissions

Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy

H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka and K. Maruyama, Chem. Commun., 2004, 1910 DOI: 10.1039/B406141A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements