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Issue 17, 2004
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Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy

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Abstract

The nido-carborane lipid 2, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid 2 formed a stable vesicle in which calcein was encapsulated. The lipid 2 was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration.

Graphical abstract: Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy

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Publication details

The article was received on 23 Apr 2004, accepted on 21 Jun 2004 and first published on 29 Jul 2004


Article type: Communication
DOI: 10.1039/B406141A
Citation: Chem. Commun., 2004,0, 1910-1911
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    Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy

    H. Nakamura, Y. Miyajima, T. Takei, S. Kasaoka and K. Maruyama, Chem. Commun., 2004, 0, 1910
    DOI: 10.1039/B406141A

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