Jump to main content
Jump to site search

Issue 18, 2004
Previous Article Next Article

The mechanism of polyleucine catalysed asymmetric epoxidation

Author affiliations

Abstract

Catalysis in the Juliá–Colonna epoxidation of α,β-unsaturated ketones is due to binding of the hydroperoxide enolate intermediate by the three N-terminal amidic N–H groups of α-helical poly-leucine; the N-terminal pair forms an oxy-anion hole, whilst the third aids displacement of hydroxide.

Graphical abstract: The mechanism of polyleucine catalysed asymmetric epoxidation

Back to tab navigation

Publication details

The article was received on 23 Mar 2004, accepted on 23 Jul 2004 and first published on 25 Aug 2004


Article type: Communication
DOI: 10.1039/B404390C
Citation: Chem. Commun., 2004,0, 2018-2020
  •   Request permissions

    The mechanism of polyleucine catalysed asymmetric epoxidation

    D. R. Kelly and S. M. Roberts, Chem. Commun., 2004, 0, 2018
    DOI: 10.1039/B404390C

Search articles by author

Spotlight

Advertisements