Issue 6, 2004

Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion protein

Abstract

A novel bis scaffold containing a pentapeptide PHGGG, derived from the prion octarepeat, forms fibrils of nanometric dimensions, thus indicating that certain segments in the unstructured region of the prion protein may facilitate an initial fibrillation event.

Graphical abstract: Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion protein

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec 2003
Accepted
23 Jan 2004
First published
10 Feb 2004

Chem. Commun., 2004, 638-639

Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion protein

C. Madhavaiah and S. Verma, Chem. Commun., 2004, 638 DOI: 10.1039/B316793C

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