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Issue 9, 2004
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Analysis of liposomal membrane composition using Raman tweezers

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Abstract

We have developed a methodology for the analysis of liposomal membranes and their contents using near-IR Raman spectroscopy on liposomes held in an optical trap. We were able to detect a variety of membrane components including lipids, cholesterol, and small molecule solutes such as ethanol, DMSO and hexafluoroisopropanol. The methodology is able to distinguish between solutes that equilibrate across the liposomal membrane from those that partition selectively into the lipid bilayer.

Graphical abstract: Analysis of liposomal membrane composition using Raman tweezers

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Publication details

The article was received on 23 Dec 2003, accepted on 17 Mar 2004 and first published on 06 Apr 2004


Article type: Communication
DOI: 10.1039/B316757G
Citation: Chem. Commun., 2004, 1120-1121
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    Analysis of liposomal membrane composition using Raman tweezers

    J. M. Sanderson and A. D. Ward, Chem. Commun., 2004, 1120
    DOI: 10.1039/B316757G

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