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Issue 22, 2004
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‘Double asymmetric induction’ as a novel tool for high stereocontrol in Baylis–Hillman reaction

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Abstract

The strategy of double asymmetric induction was utilized in Baylis–Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O-isopropylidene-α-D-glucofuranose-3-acrylate) to obtain corresponding adducts with high syn diastereoselectivities (de >90%) in moderate to good yields.

Graphical abstract: ‘Double asymmetric induction’ as a novel tool for high stereocontrol in Baylis–Hillman reaction

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Publication details

The article was received on 28 Jul 2004, accepted on 27 Aug 2004 and first published on 30 Sep 2004


Article type: Communication
DOI: 10.1039/B411548A
Citation: Chem. Commun., 2004,0, 2580-2581
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    ‘Double asymmetric induction’ as a novel tool for high stereocontrol in Baylis–Hillman reaction

    P. R. Krishna, R. Sachwani and V. Kannan, Chem. Commun., 2004, 0, 2580
    DOI: 10.1039/B411548A

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