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Issue 21, 2003
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Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

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Abstract

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.

Graphical abstract: Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

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Publication details

The article was received on 19 Jun 2003, accepted on 28 Jul 2003 and first published on 11 Aug 2003


Article type: Communication
DOI: 10.1039/B306990G
Citation: Org. Biomol. Chem., 2003,1, 3642-3644
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    Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

    D. P. Gamblin, P. Garnier, S. J. Ward, N. J. Oldham, A. J. Fairbanks and B. G. Davis, Org. Biomol. Chem., 2003, 1, 3642
    DOI: 10.1039/B306990G

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