Jump to main content
Jump to site search

Issue 12, 2003
Previous Article Next Article

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

Author affiliations

Abstract

Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional column chromatography or an aqueous work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered organic base. Hydroxyl-containing contaminants were removed by scavenging with polymer-supported tosyl chloride.

Graphical abstract: Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

Back to tab navigation

Publication details

The article was received on 08 Apr 2003, accepted on 12 May 2003 and first published on 19 May 2003


Article type: Communication
DOI: 10.1039/B303951J
Citation: Org. Biomol. Chem., 2003,1, 2029-2031
  •   Request permissions

    Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques

    R. N. MacCoss, P. E. Brennan and S. V. Ley, Org. Biomol. Chem., 2003, 1, 2029
    DOI: 10.1039/B303951J

Search articles by author

Spotlight

Advertisements