Issue 10, 2003

Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase

Abstract

The total synthesis of taurospongin A by two new approaches has been achieved where π-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.

Graphical abstract: Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase

Article information

Article type
Paper
Submitted
11 Feb 2003
Accepted
07 Apr 2003
First published
24 Apr 2003

Org. Biomol. Chem., 2003,1, 1664-1675

Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase

C. J. Hollowood, S. Yamanoi and S. V. Ley, Org. Biomol. Chem., 2003, 1, 1664 DOI: 10.1039/B301676P

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