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Issue 15, 2003
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The HLA-A2-supermotif: a QSAR definition

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Abstract

Identification of epitopes capable of binding multiple HLA types will significantly rationalise the development of epitope-based vaccines. A quantitative method assessing the contribution of each amino acid at each position was applied to over 500 nonamer peptides binding to 5 MHC alleles — A*0201, A*0202, A*0203, A*0206 and A*6802 — which together define the HLA-A2-like supertype. FXIGXI (L)IFV was identified as a supermotif for the A2-supertype based on the contributions of the common preferred amino acids at each of the nine positions. The results indicate that HLA-A*6802 is an intermediate allele standing between A2 and A3 supertypes: at anchor position 2 it is closer to A3 and at anchor position 9 it is nearer to A2. Models are available free on-line at http://www.jenner.ac.uk/MHCPred and can be used for binding affinity prediction.

Graphical abstract: The HLA-A2-supermotif: a QSAR definition

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Publication details

The article was received on 22 Jan 2003, accepted on 12 Jun 2003 and first published on 23 Jun 2003


Article type: Paper
DOI: 10.1039/B300707C
Citation: Org. Biomol. Chem., 2003,1, 2648-2654
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    The HLA-A2-supermotif: a QSAR definition

    I. Doytchinova and D. Flower, Org. Biomol. Chem., 2003, 1, 2648
    DOI: 10.1039/B300707C

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