New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

Harald Gross; Stefan Kehraus; Markus Nett; Gabriele M. König; Winfried Beil; Anthony D. Wright

doi:10.1039/B210039H

New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

Harald Gross,^a Stefan Kehraus,^a Markus Nett,^a Gabriele M. König,*^a Winfried Beil^b and Anthony D. Wright^a

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* Corresponding authors

^a Institute for Pharmaceutical Biology, University of Bonn, Nußallee 6, Germany

^b Institute for Pharmacology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Germany

Abstract

Chemical investigation of the two soft corals Nephthea sp. and Sarcophyton cherbonnieri, collected from the Fiji Islands and the Great Barrier Reef, respectively, led to the isolation of three new furano-cembranoids (1–3), two seco-cembranoid acetates (5, 6), along with the known compounds sarcoglaucol (4) and decaryiol (7). The structures of the new compounds were elucidated by employing spectroscopic techniques (NMR, MS, UV, IR and CD). Seco-cembranoids are extremely rare structures. Compounds 1, 3, and 7 were found to be cytotoxic towards several tumor cell lines (GI₅₀ values ranged from 0.15 to 8.6 µg mL⁻¹). Compound 7 arrests the cell cycle in the G2/M phase.

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Publication details

The article was received on 15 Oct 2002, accepted on 05 Feb 2003 and first published on 24 Feb 2003

Article type: Paper

DOI: 10.1039/B210039H

Citation: Org. Biomol. Chem., 2003,1, 944-949

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New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

H. Gross, S. Kehraus, M. Nett, G. M. König, W. Beil and A. D. Wright, Org. Biomol. Chem., 2003, 1, 944
DOI: 10.1039/B210039H
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Organic & Biomolecular Chemistry

New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

Abstract

Supplementary files

Publication details

New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

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