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Issue 1, 2003
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A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase

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Abstract

Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 µM).

Graphical abstract: A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase

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Publication details

The article was received on 02 Oct 2002, accepted on 22 Oct 2002 and first published on 08 Nov 2002


Article type: Communication
DOI: 10.1039/B209613G
Citation: Org. Biomol. Chem., 2003,1, 21-23
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    A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase

    R. Ahmed and F. J. Leeper, Org. Biomol. Chem., 2003, 1, 21
    DOI: 10.1039/B209613G

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