The solid-supported iodobenzoic acid derivatives 8–10 were coupled with a range of organozinc reagents 1–4 under palladium(0) catalysis. The coupled products released by acidic cleavage with TFA were obtained in high purities after recrystallisation. Analogous coupling of solid-supported (E)- and (Z)-3-iodoacrylic acids 18a, 18b, 19 and 20 gave (E)- and (Z)-α,β-unsaturated acids and amides 21–27 stereospecifically.
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Organic & Biomolecular Chemistry
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