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Issue 3, 2003
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Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows

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Abstract

Micropatterns of the electrically conjugating cardiomyocytes were prepared on a single cell level by microcontact printing (μCP), and the localized chemical stimulations were applied to the cellular pattern using multiple laminar flows. The locally delivered 1-octanol inactivated part of the myocyte patterns, while the other areas retained the activity showing spontaneous and synchronous pulsatility. Since both the cells and flows were well defined as micropatterns and each integrated on a chip, the obtained results simply demonstrate the cellular responses in a single-cell network.

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Publication details

The article was received on 22 Apr 2003, accepted on 17 Jun 2003 and first published on 01 Jul 2003


Article type: Paper
DOI: 10.1039/B304350A
Citation: Lab Chip, 2003,3, 208-211
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    Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows

    H. Kaji, M. Nishizawa and T. Matsue, Lab Chip, 2003, 3, 208
    DOI: 10.1039/B304350A

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