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Issue 2, 2003
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Synthesis and analysis of combinatorial libraries performed in an automated micro reactor system

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Abstract

This paper presents the synthesis of combinatorial libraries performed on a single-channel glass micro reactor under hydrodynamic flow control. The experiments were carried out in a non-well based micro chip and consisted of the preparation of libraries of pyrazoles by means of a Knorr reaction of 1,3-dicarbonyl compounds with hydrazines. The aim of this work is to investigate the capabilities of an automated micro reactor based system to synthesise sequentially multiple analogue reactions. Small slugs of reactants were introduced automatically by an autosampler in a serpentine-etched glass chip. The mobility of the reagents and products was achieved using hydrodynamic driven flow. Reaction slug dilution and UV slug detection took place at the outlet. A sample of the slug was analysed by using an on-line LC-UV-MS system. The degree of conversion was quantified using the UV signal and comparing with standards of starting materials and final products. After the LC-UV-MS analysis, the automated system proceeds to inject the slugs to carry out the next reaction programmed. The results suggest that the micro reactor system is capable of repeating the process of injection, mixing and reaction in an automated manner as many times as required.

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Publication details

The article was received on 03 Mar 2003, accepted on 08 Apr 2003 and first published on 24 Apr 2003


Article type: Paper
DOI: 10.1039/B302381H
Citation: Lab Chip, 2003,3, 73-76
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    Synthesis and analysis of combinatorial libraries performed in an automated micro reactor system

    E. Garcia-Egido, V. Spikmans, S. Y. F. Wong and B. H. Warrington, Lab Chip, 2003, 3, 73
    DOI: 10.1039/B302381H

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