Issue 4, 2003
From the journal:

Journal of Materials Chemistry

Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

Karl D. Pavey,*a   Stuart L. James,a   S. Elizabeth James,d   Lyuba I. Mikhalovska,a   Paul Tomlins,b   Frank Paulc  and  Sergey V. Mikhalovskya  

* Corresponding authors

a School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, Lewes Road, Brighton, UK
E-mail: k.d.pavey@bton.ac.uk

b Materials Centre, National Physical Laboratory, Queens Road, Teddington, Middlesex, UK

c Technology Development Group, GlaxoSmithKline Pharmaceuticals, NFSP (North), Third Avenue, Harlow, Essex, UK

d Blond McIndoe Research Centre, Queen Victoria Hospital, East Grinstead, West Sussex, UK

Abstract

A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.

Graphical abstract: Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

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Article information

DOI
https://doi.org/10.1039/B300989K
Article type
Communication
Submitted
24 Jan 2003
Accepted
14 Feb 2003
First published
24 Feb 2003

J. Mater. Chem., 2003,13, 654-656

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Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

K. D. Pavey, S. L. James, S. Elizabeth James, L. I. Mikhalovska, P. Tomlins, F. Paul and S. V. Mikhalovsky, J. Mater. Chem., 2003, 13, 654 DOI: 10.1039/B300989K

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