Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

John W. C. Cheing; William P. D. Goldring; Gerald Pattenden

doi:10.1039/B310753A

Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

John W. C. Cheing,^a William P. D. Goldring^a and Gerald Pattenden*^a

* Corresponding authors

^a School of Chemistry, The University of Nottingham, University Park, Nottingham, UK
E-mail: gp@nottingham.ac.uk
Fax: +44 (0)115 951 3535
Tel: +44 (0)115 951 3530

Abstract

The total syntheses of the epoxy cyclic hemiacetal structures 8 and 9, which are isomeric with the structure 6 proposed for the phomactin known as Sch 49028 isolated from the marine fungus Phoma sp. are described. Neither of these structures showed spectroscopic data consistent with those reported for the purported natural product, adding credibility to the proposal that the structure Sch 49028 does not exist in nature and that its NMR spectroscopic data should have been assigned as phomactin A (1).

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Publication details

The article was received on 04 Sep 2003, accepted on 17 Sep 2003 and first published on 11 Oct 2003

Article type: Communication

DOI: 10.1039/B310753A

Citation: Chem. Commun., 2003,0, 2788-2789

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Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

J. W. C. Cheing, W. P. D. Goldring and G. Pattenden, Chem. Commun., 2003, 0, 2788
DOI: 10.1039/B310753A
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Chemical Communications

Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

Abstract

Supplementary files

Publication details

Synthetic studies towards congeners of phomactin A. Re-examination of the structure of Sch 49028

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