Issue 20, 2003
From the journal:

Chemical Communications

A novel four-component reaction for the synthesis of functionalised dihydropyrimidines†

Danielle J. Vugts,a   Helen Jansen,a   Rob F. Schmitz,a   Frans J. J. de Kantera  and  Romano V. A. Orru*a  

* Corresponding authors

a Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
E-mail: orru@few.vu.nl
Fax: 0031204447488
Tel: 0031204447447

Abstract

In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner–Emmons/aza Diels–Alder pathway.

Graphical abstract: A novel four-component reaction for the synthesis of functionalised dihydropyrimidines

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Article information

DOI
https://doi.org/10.1039/B308243A
Article type
Communication
Submitted
18 Jul 2003
Accepted
01 Sep 2003
First published
17 Sep 2003

Chem. Commun., 2003, 2594-2595

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A novel four-component reaction for the synthesis of functionalised dihydropyrimidines

D. J. Vugts, H. Jansen, R. F. Schmitz, F. J. J. de Kanter and R. V. A. Orru, Chem. Commun., 2003, 2594 DOI: 10.1039/B308243A

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