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Issue 24, 2003
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Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

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Abstract

We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.

Graphical abstract: Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

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Publication details

The article was received on 26 Mar 2003, accepted on 27 Aug 2003 and first published on 19 Sep 2003


Article type: Feature Article
DOI: 10.1039/B303439A
Citation: Chem. Commun., 2003,0, 2949-2956
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    Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

    S. Moro, F. Deflorian, G. Spalluto, G. Pastorin, B. Cacciari, S. Kim and K. A. Jacobson, Chem. Commun., 2003, 0, 2949
    DOI: 10.1039/B303439A

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