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Issue 24, 2003
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Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

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Abstract

We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.

Graphical abstract: Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

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Publication details

The article was received on 26 Mar 2003, accepted on 27 Aug 2003 and first published on 19 Sep 2003


Article type: Feature Article
DOI: 10.1039/B303439A
Citation: Chem. Commun., 2003, 2949-2956
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    Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

    S. Moro, F. Deflorian, G. Spalluto, G. Pastorin, B. Cacciari, S. Kim and K. A. Jacobson, Chem. Commun., 2003, 2949
    DOI: 10.1039/B303439A

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