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Issue 9, 2003
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Zn-Proline catalyzed direct aldol reaction in aqueous media

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Abstract

Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature.

Graphical abstract: Zn-Proline catalyzed direct aldol reaction in aqueous media

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Publication details

The article was received on 29 Jan 2003, accepted on 10 Mar 2003 and first published on 31 Mar 2003


Article type: Communication
DOI: 10.1039/B301117H
Citation: Chem. Commun., 2003,0, 1090-1091
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    Zn-Proline catalyzed direct aldol reaction in aqueous media

    T. Darbre and M. Machuqueiro, Chem. Commun., 2003, 0, 1090
    DOI: 10.1039/B301117H

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