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Issue 4, 2003
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Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation

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Abstract

Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring dehydration leads to enhanced cytotoxicity at the low picomolar level while truncation of the side-chain at C46 results in a drastic decrease in activity.

Graphical abstract: Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation

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Publication details

The article was received on 23 Dec 2002, accepted on 15 Jan 2003 and first published on 23 Jan 2003


Article type: Communication
DOI: 10.1039/B212651F
Citation: Chem. Commun., 2003, 462-463
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    Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation

    I. Paterson, J. L. Aceña, J. Bach, D. Y.-K. Chen and M. J. Coster, Chem. Commun., 2003, 462
    DOI: 10.1039/B212651F

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