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Issue 3, 2003
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Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

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Abstract

The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.

Graphical abstract: Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

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Publication details

The article was received on 29 Nov 2002, accepted on 13 Dec 2002 and first published on 14 Jan 2003


Article type: Communication
DOI: 10.1039/B211889K
Citation: Chem. Commun., 2003,0, 316-317
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    Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

    S. J. Duncan, M. A. Cooper and D. H. Williams, Chem. Commun., 2003, 0, 316
    DOI: 10.1039/B211889K

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