Issue 3, 2003
From the journal:

Chemical Communications

A reagentless electrochemical biosensor based on a protein scaffold†

Sulay D. Jhaveri,a   J. Matthew Mauro,a   Harold M. Goldston,a   Caroline L. Schauer,a   Leonard M. Tender*a  and  Scott A. Trammell*a  

* Corresponding authors

a Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA
E-mail: mt@cbmse.nrl.navy.mil trammell@ccs.nrl.navy.mil
Fax: (202) 767-9594
Tel: 202-404-6029, 202-404-6063

Abstract

Apo-myoglobin, labeled with the environmentally sensitive redox probe RuII(NH3)4(1,10-phenanthroline-5-maleimide)2+, was immobilized onto gold electrodes modified with 11-mercaptoundecanoic acid and subsequently labeled with biotin; avidin binding to the immobilized biotin was specifically and quantitatively detected by a change in cyclic voltammetry of the co-immobilized probe.

Graphical abstract: A reagentless electrochemical biosensor based on a protein scaffold

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Article information

DOI
https://doi.org/10.1039/B209452E
Article type
Communication
Submitted
26 Sep 2002
Accepted
04 Dec 2002
First published
02 Jan 2003

Chem. Commun., 2003, 338-339

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A reagentless electrochemical biosensor based on a protein scaffold

S. D. Jhaveri, J. M. Mauro, H. M. Goldston, C. L. Schauer, L. M. Tender and S. A. Trammell, Chem. Commun., 2003, 338 DOI: 10.1039/B209452E

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