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Issue 1, 2003
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Membrane introduction mass spectrometry for monitoring complexation equilibria of β-cyclodextrin with substituted benzenes

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Abstract

Membrane introduction mass spectrometry (MIMS) was used to monitor complexation reactions between β-cyclodextrin (CD) and a series of benzene derivatives in aqueous solution. The equilibrium constants for benzene, chlorobenzene, bromobenzene, iodobenzene, toluene, cyanobenzene and nitrobenzene were determined. The suitability of MIMS for monitoring complexation reactions of organic compounds with host molecules was demonstrated. Structure–activity relationship analysis shows that the inclusion phenomena are driven by a variety of chemical forces, of which hydrophobicity is predominant for non-polar compounds, but not the only factor for more polar ones.

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Publication details

The article was received on 09 Sep 2002, accepted on 23 Nov 2002 and first published on 04 Dec 2002


Article type: Paper
DOI: 10.1039/B208770G
Citation: Analyst, 2003,128, 61-64
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    Membrane introduction mass spectrometry for monitoring complexation equilibria of β-cyclodextrin with substituted benzenes

    R. Augusti, M. Turowski and R. G. Cooks, Analyst, 2003, 128, 61
    DOI: 10.1039/B208770G

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