Issue 1, 2003

Membrane introduction mass spectrometry for monitoring complexation equilibria of β-cyclodextrin with substituted benzenes

Abstract

Membrane introduction mass spectrometry (MIMS) was used to monitor complexation reactions between β-cyclodextrin (CD) and a series of benzene derivatives in aqueous solution. The equilibrium constants for benzene, chlorobenzene, bromobenzene, iodobenzene, toluene, cyanobenzene and nitrobenzene were determined. The suitability of MIMS for monitoring complexation reactions of organic compounds with host molecules was demonstrated. Structure–activity relationship analysis shows that the inclusion phenomena are driven by a variety of chemical forces, of which hydrophobicity is predominant for non-polar compounds, but not the only factor for more polar ones.

Article information

Article type
Paper
Submitted
09 Sep 2002
Accepted
23 Nov 2002
First published
04 Dec 2002

Analyst, 2003,128, 61-64

Membrane introduction mass spectrometry for monitoring complexation equilibria of β-cyclodextrin with substituted benzenes

R. Augusti, M. Turowski and R. G. Cooks, Analyst, 2003, 128, 61 DOI: 10.1039/B208770G

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