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Issue 3, 2002
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Ionic liquids as green solvents for the asymmetric synthesis of cyanohydrins catalysed by VO(salen) complexes

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Abstract

It has been found that the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate is a good substitute solvent for CH2Cl2 to conduct the enantioselective cyanosilylation of aldehydes to their silylated cyanohydrins, using trimethylsilyl cyanide as reagent and a Schiff base vanadyl complex as catalyst. The mass balances (>90%), conversions (>80%) and enantiomeric excess (88% < ee < 90%) were high and comparable to those achieved in CH2Cl2. The ionic liquid containing the catalyst can be reused at least four times without loosing activity.

Graphical abstract: Ionic liquids as green solvents for the asymmetric synthesis of cyanohydrins catalysed by VO(salen) complexes

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Publication details

The article was received on 11 Feb 2002 and first published on 15 May 2002


Article type: Paper
DOI: 10.1039/B201497C
Citation: Green Chem., 2002,4, 272-274
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    Ionic liquids as green solvents for the asymmetric synthesis of cyanohydrins catalysed by VO(salen) complexes

    C. Baleizão, B. Gigante, H. Garcia and A. Corma, Green Chem., 2002, 4, 272
    DOI: 10.1039/B201497C

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