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Issue 6, 2002
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Parallel kinetic resolution of racemic mixtures: a new strategy for the preparation of enantiopure compounds?

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Abstract

Kinetic resolution of racemic mixtures is a well-established methodology for the preparation of optically active compounds. However, excellent enantioselectivities are required to obtain them in enantiopure form, due to the decrease in ee when conversion values are close to 50%. To overcome this limitation, a parallel (asymmetric) reaction can remove the disfavored enantiomer. In this review, several examples of this strategy showing its wide range of applicability are described, as well as their mathematical treatment and some new applications in combinatorial chemistry.

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Publication details

The article was received on 16 Jul 2002 and first published on 20 Sep 2002


Article type: Review Article
DOI: 10.1039/B205280F
Citation: Chem. Soc. Rev., 2002,31, 365-370
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    Parallel kinetic resolution of racemic mixtures: a new strategy for the preparation of enantiopure compounds?

    J. R. Dehli and V. Gotor, Chem. Soc. Rev., 2002, 31, 365
    DOI: 10.1039/B205280F

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