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Issue 17, 2002
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Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

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Abstract

A vinyl fluoride analogue of the intermediate in the reaction catalysed by type II dehydroquinase enzymes has been synthesized over seven steps from (−)-quinic acid and shown to be a potent enzyme inhibitor.

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Publication details

The article was received on 27 May 2002, accepted on 08 Jul 2002, published on 26 Jul 2002 and first published online on 26 Jul 2002


Article type: Communication
DOI: 10.1039/B205105M
Citation: Chem. Commun., 2002, 1886-1887
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    Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

    M. Frederickson, J. R. Coggins and C. Abell, Chem. Commun., 2002, 1886
    DOI: 10.1039/B205105M

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