3-Component palladium–indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides

Ian R. Cooper; Ronald Grigg; William S. MacLachlan; Mark Thornton-Pett; Visuvanathar Sridharan

doi:10.1039/B202940E

3-Component palladium–indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides

Ian R. Cooper,^a Ronald Grigg,^a William S. MacLachlan,^b Mark Thornton-Pett^a and Visuvanathar Sridharan^a

^a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds University, Leeds, UK
E-mail: R.Grigg@chem.leeds.ac.uk
Fax: +44-(0)113-233-233-6501
Tel: +44-(0)113-233-6501

^b GlaxoSmithkline, New Frontiers Science Park (North), Third Avenue, Harlow, UK

Abstract

A new palladium–indium diastereoselective cascade allylation of imines using allenes and aryl iodides is described; N-tosyl and N-aryl homoallyl amines were obtained in moderate to good yields and excellent diastereoselectivity was observed when enantiomerically pure N-tert-butanesulfinyl imines were employed in the cascade.

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Publication details

The article was received on 25 Mar 2002, accepted on 09 May 2002 and first published on 23 May 2002

Article type: Communication

DOI: 10.1039/B202940E

Citation: Chem. Commun., 2002,0, 1372-1373

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3-Component palladium–indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides

I. R. Cooper, R. Grigg, W. S. MacLachlan, M. Thornton-Pett and V. Sridharan, Chem. Commun., 2002, 0, 1372
DOI: 10.1039/B202940E
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Chemical Communications

3-Component palladium–indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides

Abstract

Supplementary files

Publication details

3-Component palladium–indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides

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