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Issue 13, 2002
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Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

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Abstract

Treatment of guanosine or 2′-deoxyguanosine with dimethyldioxirane, followed by heating in aqueous solution, generates respectively 4-amidinocarbamoyl-5-hydroxyimidazole (1) or its 2-(2,3,4-trihydroxybutyl) derivative (2).

Graphical abstract: Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

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Publication details

The article was received on 07 Feb 2002, accepted on 09 May 2002 and first published on 24 May 2002


Article type: Communication
DOI: 10.1039/B201418C
Citation: Chem. Commun., 2002,0, 1378-1379
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    Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

    R. J. H. Davies, C. Stevenson, S. Kumar, J. Lyle, L. Cosby, J. F. Malone, D. R. Boyd, N. D. Sharma, A. P. Hunter and B. K. Stein, Chem. Commun., 2002, 0, 1378
    DOI: 10.1039/B201418C

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