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Issue 11, 2002
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Morphine, the Proteus of organic molecules

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Abstract

This feature article encapsulates the senior author’s long-standing interests in opiate chemistry and attempts to place it within an historical context and against the backdrop of related work by others who have viewed morphine as one of the pinnacles of natural product synthesis. Biomimetic and ‘bioanalogous’ routes to the morphine skeleton are discussed followed by approaches based on the elaboration of phenanthrene platforms. The latter include an asymmetric synthesis of ent-morphine developed in our laboratory.

Graphical abstract: Morphine, the Proteus of organic molecules

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Publication details

The article was received on 18 Dec 2001, accepted on 14 Jan 2002 and first published on 14 Feb 2002


Article type: Feature Article
DOI: 10.1039/B111551K
Citation: Chem. Commun., 2002,0, 1159-1168
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    Morphine, the Proteus of organic molecules

    P. R. Blakemore and J. D. White, Chem. Commun., 2002, 0, 1159
    DOI: 10.1039/B111551K

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