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Issue 4, 2002
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Squalenehopene cyclase: catalytic mechanism and substrate recognition

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Abstract

Rapid progress on the catalytic mechanism and substrate recognition by squalenehopene cyclase, which has occurred only in the last several years, is reported. A series of site-directed mutation experiments and some squalene analogues have provided deep insight into the polycyclization mechanism and catalytic sites in conjunction with the information from X-ray crystal data.

Graphical abstract: Squalene–hopene cyclase: catalytic mechanism and substrate recognition

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Publication details

The article was received on 03 Oct 2001, accepted on 09 Nov 2001 and first published on 17 Jan 2002


Article type: Feature Article
DOI: 10.1039/B108995C
Citation: Chem. Commun., 2002,0, 291-301
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    Squalenehopene cyclase: catalytic mechanism and substrate recognition

    T. Hoshino and T. Sato, Chem. Commun., 2002, 0, 291
    DOI: 10.1039/B108995C

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