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Issue 11, 2002
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The use of FTICR-MS to detect chemical tags from a combinatorial library

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Abstract

The use of tagging in combinatorial chemistry permits tracking of the solid phase as it is taken through iterative split and mix cycles. Several analytical approaches to the identification of tags (and hence the chemical history of the support) have been described. We describe herein a novel chemical tagging strategy for combinatorial solid phase chemistry. The identities of the tags attached to a single bead are discovered by the high resolution, accurate mass technique of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS).

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Publication details

The article was received on 23 Apr 2002, accepted on 01 Oct 2002 and first published on 18 Oct 2002


Article type: Tutorial Review
DOI: 10.1039/B203957P
Citation: Analyst, 2002,127, 1399-1406
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    The use of FTICR-MS to detect chemical tags from a combinatorial library

    M. H. Todd and C. Abell, Analyst, 2002, 127, 1399
    DOI: 10.1039/B203957P

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