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Issue 2, 2001
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Synthesis of 3-deazathiamine

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Abstract

An efficient ten-step synthesis of deazathiamine is described. The synthesis starts from commercially available α-acetyl-γ-butyrolactone and proceeds via deamination of the key aminothiophene 6. The Gewald synthesis of thiophenes is shown to give a mixture of isomeric products with the unsymmetric ketone used here and so a modified procedure giving a single isomer is developed.

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Publication details

The article was received on 25 Aug 2000, accepted on 17 Oct 2000 and first published on 18 Dec 2000


Article type: Paper
DOI: 10.1039/B006962K
Citation: J. Chem. Soc., Perkin Trans. 1, 2001,0, 144-148
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    Synthesis of 3-deazathiamine

    D. Hawksley, D. A. Griffin and F. J. Leeper, J. Chem. Soc., Perkin Trans. 1, 2001, 0, 144
    DOI: 10.1039/B006962K

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